8-night Upper Mississippi River Cruise

September 18, 2026

American Cruise Lines: American Serenade

St. Louis/St. Paul

Vacation Offer ID 1560769

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Cruise Inclusions

Cruise
Meals
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Destination Guide
Suggested Shore Excursions

Destination	Arrival	Departure
St. Louis St. Louis 09/19/2026 Tucked away beneath the majestic limestone bluffs lies the charming port of Alton, Illinois, serving as a gateway to endless adventures in St. Louis and beyond. But before you set off on your escapades, start your journey with a visit to the captivating National Great Rivers Museum. Learn about the fascinating tales of the upper Mississippi River, exploring its extensive history, the communities it sustains, and the diverse ecosystems it nurtures.	09/19/2026	09/19/2026
St. Louis (Alton)	09/19/2026	09/19/2026
Mississippi River Cruising Mississippi River Cruising 09/20/2026 With the water views before you, relish the quiet sounds of the river. Relax on your private balcony and watch the riverbanks come to life with a vast array of wildlife that call these shores home or learn the stories of the area around you from the on-board expert. The day is yours, wander to the sun deck for the best views of the winding river. Enjoy live music, but wherever you roam, don’t forget to stop by the restaurant for freshly baked cookies at 3 pm daily.	09/20/2026	09/20/2026
Hannibal Hannibal 09/21/2026 Welcome to Hannibal, Missouri, a charming riverside town brimming with character. At the heart of Hannibal lies the legacy of its most famous resident, Mark Twain, whose childhood adventures served as the inspiration for some of literature's most beloved characters. Explore Twain's boyhood home, a beautifully preserved white clapboard house where the author spent his formative years. Nearby, the Mark Twain Boyhood Home & Museum offers a fascinating glimpse into Twain's life and works, including original manuscripts, rare artifacts, and interactive exhibits that bring his stories to life in vivid detail.	09/21/2026	09/21/2026
Mississippi River Cruising Mississippi River Cruising 09/22/2026 A day on the river is not a day lost. Grab a book, a friend, a game, or an on board expert and take the day as it comes as we navigate the Mississippi from Hannibal to Muscatine, IA. Engage in curated activities, from destination-focused enrichment programs led by esteemed guest speakers to stimulating Art and App-titude Classes, and group Cooking Demonstrations. Embrace spirited camaraderie with Mixology sessions, Trivia challenges, and Game Shows. Elevate your journey with a blend of leisure and refinement, where every moment is enriched by the timeless charm of riverboat travel.	09/22/2026	09/22/2026
Muscatine Muscatine 09/23/2026 Muscatine has a unique claim to fame as the only place where the Mighty Mississippi River runs east to west. This charming town is renowned for its history as the former largest button manufacturing area in the world, a claim to fame celebrated through local museums and historic sites. Visitors are enchanted by Muscatine's picturesque riverfront, offering stunning views and recreational opportunities such as boating and fishing.	09/23/2026	09/23/2026
Dubuque Dubuque 09/24/2026 Dubuque is a true masterpiece along the upper Mississippi River. As one of the oldest settlements west of the great river, Dubuque wears its history proudly while staying a modern hub for commerce, industry, education, and culture.	09/24/2026	09/24/2026
Winona Winona 09/25/2026 Situated in southeastern Minnesota along the banks of the upper Mississippi River, Winona is a gem of a city renowned for its stunning bluffs, picturesque riverfront, and blend of cultures.	09/25/2026	09/25/2026
Red Wing Red Wing 09/26/2026 One of the most iconic features of Red Wing is Barn Bluff, a towering limestone bluff that overlooks the city and provides panoramic views of the surrounding landscape. Hiking trails wind their way to the summit, offering outdoor enthusiasts the opportunity to experience the area's natural beauty up close.	09/26/2026	09/26/2026
St. Paul St. Paul 09/27/2026 In St. Paul, a stroll down Summit Avenue unveils a captivating array of historic mansions, each with its own story to tell from the late 1800s. For a shopping extravaganza like no other, venture into the vast expanse of the Mall of America, boasting over 500 stores alongside an indoor water park and theme park for endless entertainment.	09/27/2026	09/27/2026

American Cruise Lines: American Serenade

American Serenade won Cruise Critic’s Editors’ Picks Award for Best New River Cruise Ship of the Year recently, the first time an American ship has received this prestigious award. Introduces an updated modern interior design, integrating an elegant and refined aesthetic with tradition for the spacious comfort found aboard all of ships Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.

Ship Statistics

Maiden Voyage: 2023
Passenger Capacity: 175
Number of Staterooms: 91

Number of Suites: 16
Wheelchair Accessible: Yes

Suite

Veranda Suite (Private Balcony) (VS) Call for pricing

Category: VS
Deck 4

With a generous 405 sq. ft. of relaxing space, each Veranda suite includes a private walk-out balcony to enjoy the panoramic views. Considered one of the finest staterooms on any cruise ship, guests will enjoy full-size bathrooms and large living area with sliding glass door.

Grand Suite (Private Balcony) (GS) Call for pricing

Category: GS
Deck 4

The luxurious Grand Suite measures 650 sq. ft. and offers panoramic views through floor-to-ceiling glass windows. Sliding glass doors lead out to a private balcony complete with a private dining area, the perfect place to enjoy breakfast room service or watch the sun set. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration.

Balcony

Single (Private Balcony) (SGB) Call for pricing

Category: SGB
Deck 4
Deck 3
Deck 2

Perfect for the solo traveler, the Single staterooms offer all of the amenities you expect from a fine hotel. At 250 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Balcony Stateroom (AAR) Call for pricing

Category: AAR
Deck 1

AAR staterooms on the main deck offer complete comfort with approximately 275 sq. ft. of living space. Enjoy a full-size bathroom, large picture window, and door leading out to a furnished private balcony. These staterooms also feature a large sitting area, ideal for getting together with friends.

Balcony Stateroom (AAM) Call for pricing

Category: AAM
Deck 3

Located on the third deck, these spacious staterooms feature commanding views of the passing river landscapes. At 350 sq. ft., there is plenty of room to enjoy the tasteful comfort of your surroundings. These staterooms have all the comforts of a fine hotel and feature floor-to-ceiling sliding glass doors with a private balcony to offer panoramic views from every angle.

Balcony Stateroom (AAC) Call for pricing

Category: AAC
Deck 2

AAC staterooms are conveniently located on the second deck and offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular views of the surrounding landscape. At 316 sq. ft., these staterooms also offer a sitting area, desk and full-size bathrooms.

Fares listed are per person, based on double occupancy and include all gratuities, port charges and fees.

Prices are per person based on double occupancy. Pricing on some sailings may reflect special limited time offers, not combinable with any other offers/discounts. Valid on new bookings only. American Cruise Lines includes all shipboard meals, entertainment, tips and gratuities, alcohol, and other port charges and fees in the price of the cruise. Many shore excursions are also included in the cost of the cruise.

All fares are quoted in US Dollars.

Deck 5